Effect of SARS-CoV-2 Infection in Pregnancy on Maternal and Neonatal Outcomes in Africa: An AFREhealth Call for Evidence through Multicountry Research Collaboration Journal Articles uri icon

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  • In the African context, there is a paucity of data on SARS-CoV-2 infection and associated COVID-19 in pregnancy. Given the endemicity of infections such as malaria, HIV, and tuberculosis (TB) in sub-Saharan Africa (SSA), it is important to evaluate coinfections with SARS-CoV-2 and their impact on maternal/infant outcomes. Robust research is critically needed to evaluate the effects of the added burden of COVID-19 in pregnancy, to help develop evidence-based policies toward improving maternal and infant outcomes. In this perspective, we briefly review current knowledge on the clinical features of COVID-19 in pregnancy; the risks of preterm birth and cesarean delivery secondary to comorbid severity; the effects of maternal SARS-CoV-2 infection on the fetus/neonate; and in utero mother-to-child SARS-CoV-2 transmission. We further highlight the need to conduct multicountry surveillance as well as retrospective and prospective cohort studies across SSA. This will enable assessments of SARS-CoV-2 burden among pregnant African women and improve the understanding of the spectrum of COVID-19 manifestations in this population, which may be living with or without HIV, TB, and/or other coinfections/comorbidities. In addition, multicountry studies will allow a better understanding of risk factors and outcomes to be compared across countries and subregions. Such an approach will encourage and strengthen much-needed intra-African, south-to-south multidisciplinary and interprofessional research collaborations. The African Forum for Research and Education in Health's COVID-19 Research Working Group has embarked upon such a collaboration across Western, Central, Eastern and Southern Africa.


  • Nachega, Jean B
  • Sam-Agudu, Nadia A
  • Budhram, Samantha
  • Taha, Taha E
  • Vannevel, Valerie
  • Somapillay, Priya
  • Ishoso, Daniel Katuashi
  • Tshiasuma Pipo, Michel
  • Bongo-Pasi Nswe, Christian
  • Ditekemena, John
  • Ayele, Birhanu T
  • Machekano, Rhoderick N
  • Gachuno, Onesmus W
  • Kinuthia, John
  • Mwongeli, Nancy
  • Sekikubo, Musa
  • Musoke, Philippa
  • Agbeno, Evans Kofi
  • Umar, Lawal W
  • Ntakwinja, Mukanire
  • Mukwege, Denis M
  • Smith, Emily R
  • Mills, Edward Joseph
  • Otshudiema, John Otokoye
  • Mbala-Kingebeni, Placide
  • Kayembe, Jean-Marie N
  • Mavungu Landu, Don Jethro
  • Muyembe Tamfum, Jean-Jacques
  • Zumla, Alimuddin
  • Langenegger, Eduard J
  • Mofenson, Lynne M

publication date

  • December 28, 2020

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