Conference
Cross-Sectional Comparative Study of PK-Guided Switch between Standard Half-Life and Extended Half-Life Factor VIII Products
Abstract
Background
The high inter-individual variability in pharmacokinetics (PK) of factor VIII (FVIII) justifies the use of PK-guided prophylaxis, especially in switching between different products. A proposed definition of extended half-life (EHL) FVIII requires improvements of at least 1.3 times in half-life (t1/2) and 1.25 times the area under the curve (AUC) compared to standard half-life (SHL) products (Mahlangu et al. …
Authors
Megias JE; Boix SB; García MFM; Berrueco R; Mingot-Castellano ME; López MR; Canaro M; Arranz JM; Leciñena IL; Haya S
Volume
134
Publisher
American Society of Hematology
Publication Date
November 13, 2019
DOI
10.1182/blood-2019-127946
Conference proceedings
Blood
Issue
Supplement_1
ISSN
0006-4971