Journal article
CARM1 Regulates AMPK Signaling in Skeletal Muscle
Abstract
Coactivator-associated arginine methyltransferase 1 (CARM1) is an emerging mediator of skeletal muscle plasticity. We employed genetic, physiologic, and pharmacologic approaches to determine whether CARM1 regulates the master neuromuscular phenotypic modifier AMP-activated protein kinase (AMPK). CARM1 skeletal muscle-specific knockout (mKO) mice displayed reduced muscle mass and dysregulated autophagic and atrophic processes downstream of AMPK. …
Authors
Stouth DW; vanLieshout TL; Ng SY; Webb EK; Manta A; Moll Z; Ljubicic V
Journal
iScience, Vol. 23, No. 11,
Publisher
Elsevier
Publication Date
November 2020
DOI
10.1016/j.isci.2020.101755
ISSN
2589-0042