Journal article
GABAergic polygenic risk for cocaine use disorder is negatively correlated with precuneus activity during cognitive control in African American individuals
Abstract
Impaired cognitive control has been implicated in cocaine use disorder (CUD). GABAergic treatments have been proposed for CUD. Here we examined relationships between GABAergic genes and neural correlates of cognitive control in CUD. We analyzed two independent African American cohorts: one of >3000 genomewide-genotyped subjects with substance dependence and another of 40 CUD and 22 healthy control (HC) subjects who were exome-array genotyped …
Authors
Yang B-Z; Balodis IM; Kober H; Worhunsky PD; Lacadie CM; Gelernter J; Potenza MN
Journal
Addictive Behaviors, Vol. 114, ,
Publisher
Elsevier
Publication Date
March 2021
DOI
10.1016/j.addbeh.2020.106695
ISSN
0306-4603