Refining evidence-based retinopathy of prematurity screening guidelines: The SCREENROP study Journal Articles uri icon

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abstract

  • AbstractPurposeRetinopathy of prematurity (ROP) is a potentially blinding condition affecting premature infants for which less than 10% of babies undergoing screening require treatment. This study assessed and validated predictors of developing clinically significant ROP (type 2 or worse) and ROP requiring treatment.DesignNationwide retrospective cohort study.MethodsThis study included infants born between January 2014 and June 2016, admitted to level 3 neonatal intensive care units across Canada who underwent ROP screening. Data were derived from the Canadian Neonatal Network database. Predefined ≥ 1% risk for clinically significant retinopathy or prematurity and ROP requiring treatment was set as threshold for screening. Thirty-two potential predictors were analyzed, to identify and validate the most important ones for predicting clinically significant ROP. The predictors were determined on a derivation cohort and tested on a validation cohort. Multivariable logistic regression modeling was used for analysis.ResultsUsing a sample of 4,888 babies and analyzing 32 potential predictors, capturing babies with ≥1% risk of developing clinically significant ROP equated to screening babies with birth weight (BW) <1,300 g or gestational age (GA) <30 weeks while capturing babies with ≥1% risk of requiring ROP treatment equated to screening babies with BW <1,200 g or GA <29 weeks.ConclusionsThe Canadian ROP screening criteria can be modified to screen babies with BW <1,200 g or GA <30 weeks. Using these criteria, babies requiring treatment would be identified while reducing the number of babies screened unnecessarily.

authors

  • Sabri, Kourosh
  • Shivananda, Sandesh
  • Farrokhyar, Forough
  • Selvitella, Alessandro
  • Easterbrook B Kin, Bethany
  • Seidlitz, Wendy
  • Lee, Shoo K
  • Whelan, Kaitlyn
  • Shah, Prakesh S
  • Gardiner, Jane
  • Ye, Xiang Y
  • Budning, Andrew
  • Clark, Ian
  • Erraguntla, Vasudha
  • Fournier, Anick
  • Hamel, Patrick
  • Heon, Elise
  • Isaza-Zapata, Gloria
  • Lyons, Christopher
  • MacDonald, Ian
  • Makar, Inas
  • Kertes, Peter
  • Greve, Mark
  • Tennant, Matthew
  • Mireskandari, Kamiar
  • Nazemi, Fariba
  • O’Connor, Michael
  • Ospina, Luis
  • Pegado, Victor
  • Robitaille, Johane
  • Sharan, Sapna
  • Sigesmund, Dayle
  • Solarte, Carlos
  • Strube, Yi Ning
  • Superstein, Rosanne
  • Tehrani, Nasrin
  • Mulholland, Conor
  • Nabi, Naeem
  • Synnes, Anne
  • Ting, Joseph
  • Rouvinez-Bouali, Nicole
  • Piedboeuf, Bruno
  • Drolet, Christine
  • Bertelle, Valerie
  • Masse, Edith
  • Makary, Hala
  • Yee, Wendy
  • Harrison, Adele
  • Seshia, Molly
  • Barrington, Keith
  • Afifi, Jehier
  • Deshpandey, Akhil
  • Pelausa, Ermelinda
  • Dow, Kimberly
  • Riley, Patricia
  • Claveau, Martine
  • Aziz, Khalid
  • Cieslak, Zenon
  • Kalapesi, Zarin
  • Sankaran, Koravangattu
  • Faucher, Daniel
  • Alvaro, Ruben
  • Canning, Roderick
  • da Silva, Orlando
  • Ojah, Cecil
  • Monterrosa, Luis
  • Dunn, Michael
  • Sorokan, Todd
  • Kajetanowicz, Andrzej
  • Nwaesei, Chuks
  • Fajardo, Carlos
  • Husain, Sahira
  • Xia, Sunny
  • Viscardi, Virginia
  • Yeh, Sonny
  • Schneider, Laura
  • Whelan, Kaitlyn
  • Shah, Prakesh S
  • Gardiner, Jane
  • Ye, Xiang Y
  • Budning, Andrew
  • Clark, Ian
  • Erraguntla, Vasudha
  • Fournier, Anick
  • Hamel, Patrick
  • Heon, Elise
  • Isaza-Zapata, Gloria
  • Lyons, Christopher
  • MacDonald, Ian
  • Makar, Inas
  • Kertes, Peter
  • Greve, Mark
  • Tennant, Matthew
  • Mireskandari, Kamiar
  • Nazemi, Fariba
  • O’Connor, Michael
  • Ospina, Luis
  • Pegado, Victor
  • Robitaille, Johane
  • Sharan, Sapna
  • Sigesmund, Dayle
  • Solarte, Carlos
  • Strube, Yi Ning
  • Superstein, Rosanne
  • Tehrani, Nasrin
  • Mulholland, Conor
  • Nabi, Naeem
  • Synnes, Anne
  • Ting, Joseph
  • Rouvinez-Bouali, Nicole
  • Piedboeuf, Bruno
  • Drolet, Christine
  • Bertelle, Valerie
  • Masse, Edith
  • Makary, Hala
  • Yee, Wendy
  • Harrison, Adele
  • Seshia, Molly
  • Barrington, Keith
  • Afifi, Jehier
  • Deshpandey, Akhil
  • Pelausa, Ermelinda
  • Dow, Kimberly
  • Riley, Patricia
  • Claveau, Martine
  • Aziz, Khalid
  • Cieslak, Zenon
  • Kalapesi, Zarin
  • Sankaran, Koravangattu
  • Faucher, Daniel
  • Alvaro, Ruben
  • Canning, Roderick
  • da Silva, Orlando
  • Ojah, Cecil
  • Monterrosa, Luis
  • Dunn, Michael
  • Sorokan, Todd
  • Kajetanowicz, Andrzej
  • Nwaesei, Chuks
  • Fajardo, Carlos
  • Husain, Sahira
  • Xia, Sunny
  • Viscardi, Virginia
  • Yeh, Sonny
  • Schneider, Laura

publication date

  • November 2, 2020