[Granulocyte-Colony Stimulating Factors as adjunctive therapy in patients with neutropenic fever]. Academic Article uri icon

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  • Chemotherapy induced neutropenic fever requires a hospitalization in 20-30 % of cases and is then associated with a mortality above 10 %. Hospitalized patients require strict isolation, which sometimes results in a substantial physical and psychological burden. Granulocyte-colony stimulating factors (G-CSF) are established in the primary and secondary prevention of chemotherapy-induced neutropenia. However, their role as adjunctive therapy in patients with neutropenic fever is less clear. This review resumes current best evidence in this area and discusses current recommendations.


  • Buchs, Elisa
  • Chalandon, Yves
  • Friedlaender, Alex
  • Stirnemann, Jérôme
  • Agoritsas, Thomas

publication date

  • October 21, 2020