An interbacterial toxin inhibits target cell growth by synthesizing (p)ppApp

Bacteria have evolved sophisticated mechanisms to inhibit the growth of competitors. One such mechanism involves type VI secretion systems, which can be used by bacteria to directly inject antibacterial toxins into neighbouring cells. Many of these toxins target cell envelope integrity, but the full range of growth inhibitory mechanisms remains to be determined. Here, we discover a novel type VI secretion effector, Tas1, in the opportunistic …