Genome-wide association study identifies 48 common genetic variants associated with handedness Academic Article uri icon

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abstract

  • Handedness has been extensively studied because of its relationship with language and the over-representation of left-handers in some neurodevelopmental disorders. Using data from the UK Biobank, 23andMe and the International Handedness Consortium, we conducted a genome-wide association meta-analysis of handedness (N = 1,766,671). We found 41 loci associated (P < 5 × 10-8) with left-handedness and 7 associated with ambidexterity. Tissue-enrichment analysis implicated the CNS in the aetiology of handedness. Pathways including regulation of microtubules and brain morphology were also highlighted. We found suggestive positive genetic correlations between left-handedness and neuropsychiatric traits, including schizophrenia and bipolar disorder. Furthermore, the genetic correlation between left-handedness and ambidexterity is low (rG = 0.26), which implies that these traits are largely influenced by different genetic mechanisms. Our findings suggest that handedness is highly polygenic and that the genetic variants that predispose to left-handedness may underlie part of the association with some psychiatric disorders.

authors

  • Cuellar-Partida, Gabriel
  • Tung, Joyce Y
  • Eriksson, Nicholas
  • Albrecht, Eva
  • Aliev, Fazil
  • Andreassen, Ole A
  • Barroso, Inês
  • Beckmann, Jacques S
  • Boks, Marco P
  • Boomsma, Dorret I
  • Boyd, Heather A
  • Breteler, Monique MB
  • Campbell, Harry
  • Chasman, Daniel I
  • Cherkas, Lynn F
  • Davies, Gail
  • de Geus, Eco JC
  • Deary, Ian J
  • Deloukas, Panos
  • Dick, Danielle M
  • Duffy, David L
  • Eriksson, Johan G
  • Esko, Tõnu
  • Feenstra, Bjarke
  • Geller, Frank
  • Gieger, Christian
  • Giegling, Ina
  • Gordon, Scott D
  • Han, Jiali
  • Hansen, Thomas F
  • Hartmann, Annette M
  • Hayward, Caroline
  • Heikkilä, Kauko
  • Hicks, Andrew A
  • Hirschhorn, Joel N
  • Hottenga, Jouke-Jan
  • Huffman, Jennifer E
  • Hwang, Liang-Dar
  • Ikram, M Arfan
  • Kaprio, Jaakko
  • Kemp, John P
  • Khaw, Kay-Tee
  • Klopp, Norman
  • Konte, Bettina
  • Kutalik, Zoltan
  • Lahti, Jari
  • Li, Xin
  • Loos, Ruth JF
  • Luciano, Michelle
  • Magnusson, Sigurdur H
  • Mangino, Massimo
  • Marques-Vidal, Pedro
  • Martin, Nicholas G
  • McArdle, Wendy L
  • McCarthy, Mark I
  • Medina-Gomez, Carolina
  • Melbye, Mads
  • Melville, Scott A
  • Metspalu, Andres
  • Milani, Lili
  • Mooser, Vincent
  • Nelis, Mari
  • Nyholt, Dale R
  • O’Connell, Kevin S
  • Ophoff, Roel A
  • Palmer, Cameron
  • Palotie, Aarno
  • Palviainen, Teemu
  • Pare, Guillaume
  • Paternoster, Lavinia
  • Peltonen, Leena
  • Penninx, Brenda WJH
  • Polasek, Ozren
  • Pramstaller, Peter P
  • Prokopenko, Inga
  • Raikkonen, Katri
  • Ripatti, Samuli
  • Rivadeneira, Fernando
  • Rudan, Igor
  • Rujescu, Dan
  • Smit, Johannes H
  • Smith, George Davey
  • Smoller, Jordan W
  • Soranzo, Nicole
  • Spector, Tim D
  • Pourcain, Beate St
  • Starr, John M
  • Stefánsson, Hreinn
  • Steinberg, Stacy
  • Teder-Laving, Maris
  • Thorleifsson, Gudmar
  • Stefánsson, Kári
  • Timpson, Nicholas J
  • Uitterlinden, André G
  • van Duijn, Cornelia M
  • van Rooij, Frank JA
  • Vink, Jaqueline M
  • Vollenweider, Peter
  • Vuoksimaa, Eero
  • Waeber, Gérard
  • Wareham, Nicholas J
  • Warrington, Nicole
  • Waterworth, Dawn
  • Werge, Thomas
  • Wichmann, H-Erich
  • Widen, Elisabeth
  • Willemsen, Gonneke
  • Wright, Alan F
  • Wright, Margaret J
  • Xu, Mousheng
  • Zhao, Jing Hua
  • Kraft, Peter
  • Hinds, David A
  • Lindgren, Cecilia M
  • Mägi, Reedik
  • Neale, Benjamin M
  • Evans, David M
  • Medland, Sarah E

publication date

  • January 2021