Novel Antibiotics May Be Noninferior but Are They Becoming Less Effective?: a Systematic Review Academic Article uri icon

  • Overview
  • Research
  • Identity
  • Additional Document Info
  • View All


  • ABSTRACT Novel antibiotics approved by noninferiority trials may become less effective over time in two scenarios: (i) the treatment effect in studies of novel antibiotics may be consistently worse than studies of older antibiotics; (ii) when a decreasingly effective control arm is used in a series of noninferiority trials. Our systematic review of 175 noninferiority antibiotic trials found these scenarios to be rare.


  • Bai, Anthony D
  • Komorowski, Adam S
  • Lo, Carson KL
  • Tandon, Pranav
  • Li, Xena X
  • Mokashi, Vaibhav
  • Cvetkovic, Anna
  • Findlater, Aidan
  • Liang, Laurel
  • Loeb, Mark
  • Mertz, Dominik

publication date

  • September 8, 2020