Prospective Surveillance and Risk Reduction of Cancer Treatment–Related Lymphedema: Systematic Review and Meta-Analysis Academic Article uri icon

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  • PROBLEM IDENTIFICATION: Secondary lymphedema is a chronic condition that may result from cancer-related treatments. Evidence is emerging on prospective surveillance and risk reduction. LITERATURE SEARCH: Databases were systematically searched through April 1, 2019, for comparative studies evaluating interventions aiming to prevent lymphedema in patients with cancer. DATA EVALUATION: A random-effects model was used to perform meta-analysis, when appropriate. SYNTHESIS: A total of 26 studies (4,095 patients) were included, with 23 providing data sufficient for meta-analysis. Surveillance programs increased the likelihood of detecting lymphedema. Physiotherapy, exercise programs, and delayed exercise reduced the incidence of lymphedema. IMPLICATIONS FOR RESEARCH: Future research should standardize (a) evidence-based interventions to reduce the development of lymphedema and increase the likelihood of early detection and (b) outcome measures to build a body of evidence that leads to practice change. SUPPLEMENTAL MATERIAL CAN BE FOUND AT HTTPS: //


  • Ding, Jingyi
  • Hasan, Bashar
  • Malandris, Konstantinos
  • Farah, Magdoleen
  • Manolopoulos, Apostolos
  • Ginex, Pamela
  • Anbari, Allison
  • Nayfeh, Tarek
  • Rajjoub, Moutie
  • Benkhadra, Raed
  • Prokop, Larry
  • Morgan, Rebecca
  • Murad, M Hassan

publication date

  • September 1, 2020