Journal article
Effectiveness of cholinesterase inhibitors and memantine for treating dementia: evidence review for a clinical practice guideline.
Abstract
BACKGROUND: The effectiveness of the 5 U.S. Food and Drug Administration-approved pharmacologic therapies for dementias in achieving clinically relevant improvements is unclear.
PURPOSE: To review the evidence for the effectiveness of cholinesterase inhibitors (donepezil, galantamine, rivastigmine, and tacrine) and the neuropeptide-modifying agent memantine in achieving clinically relevant improvements, primarily in cognition, global function, …
Authors
Raina P; Santaguida P; Ismaila A; Patterson C; Cowan D; Levine M; Booker L; Oremus M
Journal
Annals of Internal Medicine, Vol. 148, No. 5, pp. 379–397
Publisher
American College of Physicians
Publication Date
March 4, 2008
DOI
10.7326/0003-4819-148-5-200803040-00009
ISSN
1056-8751