A direct linear reconstruction method for spectrally resolved 3D bioluminescence tomography

Spectrally-resolved BioLuminescence optical Tomography (sBLT) is used to recover images of Luciferase activity within a 3D mouse model using multi-wavelength emission data from multiple internal bioluminescence sources. The images show that the location of sources can be reconstructed accurately using a fast, direct and linear reconstruction algorithm. © 2006 Optical Society of America.