Journal article
Ribbon of DNA Lattice on Gold Nanoparticles for Selective Drug Delivery to Cancer Cells
Abstract
Herein, we report on the design of a programmable DNA ribbon using long-chain DNA molecules with a user-defined repetitive padlock sequence. The DNA ribbon can be further combined with gold nanoparticles (AuNPs) to create a composite nanomaterial that contains an AuNP core and a high-density DNA crown carrying a cancer-cell-targeting DNA aptamer, a fluorescent tag for location tracking, and a cell-killing drug. This composite material can be …
Authors
Zhang S; Chen C; Xue C; Chang D; Xu H; Salena BJ; Li Y; Wu Z
Journal
Angewandte Chemie International Edition, Vol. 59, No. 34, pp. 14584–14592
Publisher
Wiley
Publication Date
August 17, 2020
DOI
10.1002/anie.202005624
ISSN
1433-7851