Impact of Inter- and Intramuscular Fat on Muscle Architecture and Capacity

There are factors that could affect both muscle architecture and muscle capacity, such as aging, chronic disease, and lifestyle. Few studies have investigated the relationship between muscle fat infiltration, muscle architecture, and muscle capacity. Therefore, a summary and evaluation of the measurements and findings in the existing literature can provide a better understanding of both the effects of age and the pathophysiology of different diseases. Additionally, there are several different measurement tools used to assess fat infiltration in muscle, such as magnetic resonance imaging (MRI), dual-energy X-ray absorptiometry (DEXA), and ultrasound (US). However, the reliability and validity of B-mode US for quantifying different muscle architecture parameters, including fat infiltration and muscle quality, need to be determined.