Journal article
Utilising red cell antigen genotyping and serological phenotyping in sickle cell disease patients to risk‐stratify patients for alloimmunisation risk
Abstract
BACKGROUND: Alloimmunisation and haemolytic transfusion reactions (HTRs) can occur in patients with sickle cell disease (SCD) despite providing phenotype-matched red blood cell (RBC) transfusions. Variant RBC antigen gene alleles/polymorphisms can lead to discrepancies in serological phenotyping. We evaluated differences between RBC antigen genotyping and phenotyping methods and retrospectively assessed if partial antigen expression may lead to …
Authors
Shih AW; Yan MTS; Elahie AL; Barty RL; Liu Y; Berardi P; Azzam M; Siddiqui R; Parvizian MK; Mcdougall T
Journal
Transfusion Medicine, Vol. 30, No. 4, pp. 263–274
Publisher
Wiley
Publication Date
August 2020
DOI
10.1111/tme.12685
ISSN
0958-7578