Functional Disability 5 Years after Acute Respiratory Distress Syndrome Journal Articles uri icon

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  • BACKGROUND: There have been few detailed, in-person interviews and examinations to obtain follow-up data on 5-year outcomes among survivors of the acute respiratory distress syndrome (ARDS). METHODS: We evaluated 109 survivors of ARDS at 3, 6, and 12 months and at 2, 3, 4, and 5 years after discharge from the intensive care unit. At each visit, patients were interviewed and examined; underwent pulmonary-function tests, the 6-minute walk test, resting and exercise oximetry, chest imaging, and a quality-of-life evaluation; and reported their use of health care services. RESULTS: At 5 years, the median 6-minute walk distance was 436 m (76% of predicted distance) and the Physical Component Score on the Medical Outcomes Study 36-Item Short-Form Health Survey was 41 (mean norm score matched for age and sex, 50). With respect to this score, younger patients had a greater rate of recovery than older patients, but neither group returned to normal predicted levels of physical function at 5 years. Pulmonary function was normal to near-normal. A constellation of other physical and psychological problems developed or persisted in patients and family caregivers for up to 5 years. Patients with more coexisting illnesses incurred greater 5-year costs. CONCLUSIONS: Exercise limitation, physical and psychological sequelae, decreased physical quality of life, and increased costs and use of health care services are important legacies of severe lung injury.


  • Herridge, Margaret S
  • Tansey, Catherine M
  • Matté, Andrea
  • Tomlinson, George
  • Diaz-Granados, Natalia
  • Cooper, Andrew
  • Guest, Cameron B
  • Mazer, C David
  • Mehta, Sangeeta
  • Stewart, Thomas
  • Kudlow, Paul
  • Cook, Deborah
  • Slutsky, Arthur S
  • Cheung, Angela M

publication date

  • April 7, 2011

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