Journal article
A GM-CSF/IL-33 Pathway Facilitates Allergic Airway Responses to Sub-Threshold House Dust Mite Exposure
Abstract
Allergic asthma is a chronic immune-inflammatory disease of the airways. Despite aeroallergen exposure being universal, allergic asthma affects only a fraction of individuals. This is likely related, at least in part, to the extent of allergen exposure. Regarding house dust mite (HDM), we previously identified the threshold required to elicit allergic responses in BALB/c mice. Here, we investigated the impact of an initial immune perturbation …
Authors
Llop-Guevara A; Chu DK; Walker TD; Goncharova S; Fattouh R; Silver JS; Moore CL; Xie JL; O’Byrne PM; Coyle AJ
Journal
PLOS ONE, Vol. 9, No. 2,
Publisher
Public Library of Science (PLoS)
DOI
10.1371/journal.pone.0088714
ISSN
1932-6203