Journal article
A phenome-wide association study of a lipoprotein-associated phospholipase A2 loss-of-function variant in 90 000 Chinese adults
Abstract
BACKGROUND: Lipoprotein-associated phospholipase A2 (Lp-PLA2) has been implicated in development of atherosclerosis; however, recent randomized trials of Lp-PLA2 inhibition reported no beneficial effects on vascular diseases. In East Asians, a loss-of-function variant in the PLA2G7 gene can be used to assess the effects of genetically determined lower Lp-PLA2 METHODS: PLA2G7 V279F (rs76863441) was genotyped in 91 428 individuals randomly …
Authors
Millwood IY; Bennett DA; Walters RG; Clarke R; Waterworth D; Johnson T; Chen Y; Yang L; Guo Y; Bian Z
Journal
International Journal of Epidemiology, Vol. 45, No. 5, pp. 1588–1599
Publisher
Oxford University Press (OUP)
Publication Date
10 2016
DOI
10.1093/ije/dyw087
ISSN
0300-5771