A General Approach to the Construction of Structure‐Switching Reporters from RNA Aptamers

Three in one: A three‐component, duplex‐to‐complex structure‐switching system is a simple and general strategy for the construction of fluorescent reporters from existing RNA aptamers (see picture). The tagging strategy is attractive as it circumvents the need for the chemical synthesis of modified RNA, and the structure‐switching reporters can be used to distinguish targets that have very similar chemical structures.