Journal article
IL-10 produced by trophoblast cells inhibits phagosome maturation leading to profound intracellular proliferation of Salmonella enterica Typhimurium
Abstract
INTRODUCTION: Salmonella enterica Typhimurium (ST) is a phagosomal pathogen that can infect placental trophoblast cells leading to abortion and severe maternal illness. It is unclear how the trophoblast cells promote profound bacterial proliferation.
METHODS: The mechanism of internalization, intracellular growth and phagosomal biogenesis in ST-infected human epithelial (HeLa), macrophage (THP-1) and trophoblast-derived cell lines (JEG-3, BeWo …
Authors
Nguyen T; Robinson N; Allison SE; Coombes BK; Sad S; Krishnan L
Journal
Placenta, Vol. 34, No. 9, pp. 765–774
Publisher
Elsevier
Publication Date
September 2013
DOI
10.1016/j.placenta.2013.06.003
ISSN
0143-4004
Associated Experts
Fields of Research (FoR)
Sustainable Development Goals (SDG)
Medical Subject Headings (MeSH)
Bacterial ProteinsBiomarkersCell LineCell ProliferationColony Count, MicrobialEpithelial CellsHumansInterleukin-10Lysosomal-Associated Membrane Protein 1LysosomesMacrophagesMembrane FusionMicrobial ViabilityMutationPhagocytosisPhagosomesSalmonella typhimuriumTrophoblastsUp-Regulationrab5 GTP-Binding Proteins