The effect of cimetidine on pepsin secretion in patients with Zollinger Ellison Syndrome Academic Article uri icon

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abstract

  • SummaryWe have measured pepsin output in two patients with Zollinger Ellison Syndrome before and after an intravenous dose of cimetidine. Pepsin output increased after H2 blockade in both patients despite a decrease in both the volume and acidity of secretion. We suggest that nonresponse to cimetidine may be due to increased pepsin secretion when receiving treatment.

publication date

  • December 1983