Comprehensive stereological assessment of the human lung using multiresolution computed tomography Academic Article uri icon

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  • Stereology has been the gold standard to quantify the three-dimensional lung anatomy using two-dimensional microscopy images. However, such techniques are labor intensive. This study provides a method that applies stereology to volumetric computed tomography images of frozen whole human lungs and systematic uniform random samples. The method yielded a comprehensive data set on the small airways and parenchymal lung structures, highlighting morphometric sex differences and providing a reference data set for future pathological studies.


  • Vasilescu, Dragoş M
  • Phillion, Andre
  • Kinose, Daisuke
  • Verleden, Stijn E
  • Vanaudenaerde, Bart M
  • Verleden, Geert M
  • Van Raemdonck, Dirk
  • Stevenson, Christopher S
  • Hague, Cameron J
  • Han, MeiLan K
  • Cooper, Joel D
  • Hackett, Tillie-Louise
  • Hogg, James C

publication date

  • June 1, 2020