Journal article
Multiple Breath Nitrogen Washout: A Feasible Alternative to Mass Spectrometry
Abstract
BACKGROUND: The lung clearance index (LCI), measured by multiple breath washout (MBW), reflects global ventilation inhomogeneity and is a sensitive marker of early cystic fibrosis (CF) lung disease. Current evidence is based on a customized mass spectrometry system that uses sulfur hexafluoride (SF6) as a tracer gas, which is not widely available. Nitrogen (N2) washout may be better suited for clinical use and multi-center trials.
OBJECTIVE: To …
Authors
Jensen R; Stanojevic S; Gibney K; Salazar JG; Gustafsson P; Subbarao P; Ratjen F
Journal
PLOS ONE, Vol. 8, No. 2,
Publisher
Public Library of Science (PLoS)
Publication Date
2013
DOI
10.1371/journal.pone.0056868
ISSN
1932-6203