Cranial MR and proton MR spectroscopy findings in hemophagocytic lymphohistiocytosis

Hemophagocytic lymphohistiocytosis (HLH) is a nonmalignant disorder of immune regulation, with overproduction of cytokines and diminished immune surveillance. Symptoms are nonspecific and may affect multiple organs, including the central nervous system (CNS). Seizures, focal neurologic deficits, and gait abnormalities are the most common neurologic manifestations. Neuroimaging findings have been described in case reports and small series; …