Long-term potentiation trains induce mossy fiber sprouting

It has been shown that both amygdaloid and hippocampal kindling induce sprouting of the mossy fibers in the dentate gyrus. In this study, we investigated whether non-epileptogenic stimulation could also induce mossy fiber sprouting. Long-term potentiation (LTP) was induced in the dentate gyrus by the application of brief, high frequency trains to the perforant path. The potentiating stimulation was applied each day for 10 days, and the tissue …