Journal article
Brain-derived neurotrophic factor infusion delays amygdala and perforant path kindling without affecting paired-pulse measures of neuronal inhibition in adult rats
Abstract
Kindling is an animal model of human temporal lobe epilepsy in which excitability in limbic structures is permanently enhanced by repeated stimulations. Kindling also increases the expression of nerve growth factor, brain-derived neurotrophic factor, and brain-derived neurotrophic factor receptor messenger RNAs in both the hippocampus and cerebral cortex and causes structural changes in the hippocampus including hilar hypertrophy. We have …
Authors
Osehobo P; Adams B; Sazgar M; Xu Y; Racine RJ; Fahnestock M
Journal
Neuroscience, Vol. 92, No. 4, pp. 1367–1375
Publisher
Elsevier
Publication Date
June 1999
DOI
10.1016/s0306-4522(99)00048-2
ISSN
0306-4522