Journal article
The effects of brain-derived neurotrophic factor (BDNF) administration on kindling induction, Trk expression and seizure-related morphological changes
Abstract
Brain-derived neurotrophic factor (BDNF) is a member of the neurotrophin family that mediates synaptic plasticity and excitability in the CNS. Recent evidence has shown that increased BDNF levels can lead to hyperexcitability and epileptiform activities, while suppression of BDNF function in transgenic mice or by antagonist administration retards the development of seizures. However, several groups, including our own, have reported that …
Authors
Xu B; Michalski B; Racine RJ; Fahnestock M
Journal
Neuroscience, Vol. 126, No. 3, pp. 521–531
Publisher
Elsevier
Publication Date
1 2004
DOI
10.1016/j.neuroscience.2004.03.044
ISSN
0306-4522