Journal article
Cholinotrophic molecular substrates of mild cognitive impairment in the elderly.
Abstract
Cholinergic nucleus basalis (NB) neurons provide the major cholinergic innervation to the cortical mantle, are selectively vulnerable in late stage Alzheimer's disease (AD) and require the neurotrophin, nerve growth factor (NGF) and its receptors (TrkA and p75(NTR)), for their survival. The molecular events underlying the demise of these neurons in AD were investigated using tissue harvested from participants in a longitudinal clinical …
Authors
Mufson EJ; Counts SE; Fahnestock M; Ginsberg SD
Journal
Current Alzheimer Research, Vol. 4, No. 4, pp. 340–350
Publisher
Bentham Science Publishers
Publication Date
September 2007
DOI
10.2174/156720507781788855
ISSN
1567-2050