Journal article
Altered Balance of Proteolytic Isoforms of Pro-Brain-Derived Neurotrophic Factor in Autism
Abstract
Defects in synaptic development and plasticity may lead to autism. Brain-derived neurotrophic factor (BDNF) plays a critical role in synaptogenesis and synaptic plasticity. BDNF is synthesized as a precursor, pro-BDNF, which can be processed into either a truncated form or into mature BDNF. Previous studies reported increased BDNF-immunoreactive protein in autism, but the mechanism of this increase has not been investigated. We examined BDNF …
Authors
Garcia KLP; Yu G; Nicolini C; Michalski B; Garzon DJ; Chiu VS; Tongiorgi E; Szatmari P; Fahnestock M
Journal
Journal of Neuropathology & Experimental Neurology, Vol. 71, No. 4, pp. 289–297
Publisher
Oxford University Press (OUP)
Publication Date
April 2012
DOI
10.1097/nen.0b013e31824b27e4
ISSN
0022-3069