Effect of Whole Body Hyperthermia and BCNU on the...

Effect of Whole Body Hyperthermia and BCNU on the Development of Radiation Myelitis in the Rat

Abstract

A radiant heat device was used to study the interaction of 41.8 degrees C whole body hyperthermia (WBH), radiation (40 Gy) and the lipophilic anti-neoplastic agent BCNU in the development of myelitis in the rat spinal cord. The addition of WBH and BCNU neither precipitated myelitis acutely nor shortened the latency before the onset of neurological signs in irradiated animals.

Authors

Neville AJ; Robins HI; Martin P; Gilchrist KW; Dennis WH; Steeves RA

Journal

International Journal of Radiation Biology, Vol. 46, No. 4, pp. 417–420

Publisher

Taylor & Francis

Publication Date

January 1, 1984

DOI

10.1080/09553008414551601

ISSN

0955-3002

Associated Experts

Alan Neville

Professor Emeritus, Faculty of Health Sciences

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