The relationship between inflammation and cancer has long been discussed, ever since Virchow first postulated the role of chronic inflammation in the onset of cancer. Though much research since then has focused on inflammation-induced cancer, it is of equal importance to consider the impact tumour cells can have on the immune system. Stemming from the broader concept of “oncodynamics”, this chapter will discuss cancer-induced inflammation and immunosuppression caused by the release of tumour-derived factors that act on the body’s immune cells.