Matrix metalloproteinases and the immune response

The timely breakdown of the extracellular matrix (ECM) is essential in many physiological and biological processes. The matrix-degradation process involves tissue remodeling and immune/inflammatory reactions that occur in the stroma. Thus, the proteolytic and destructive potential of the matrix metalloproteinase (MMP) family is a major concern in several pathological conditions involving ECM degradation. This review details the structures and functions of MMPs and presents an overview of the interaction of MMPs with components of the immune system.