Attenuation of pulmonary vascular remodelling by natriuretic peptides

Atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP), cardiac hormones showing similarity in biological actions and amino acid sequence, are synthesized and secreted by atrial and ventricular tissue during pulmonary vascular remodelling. In the isolated and perfused rat lung preparation ANP and BNP are equipotent in attenuating hypoxic pulmonary vasoconstriction (HPV) in the normal and the remodelled circulation. Synthesis and …