Endothelial cell derived growth factors in pulmonary vascular hypertension

In pulmonary hypertension there is remodelling of the pulmonary vessels. This renders the vasculature unresponsive to vasodilators and hence once this remodelling has occurred, patients are difficult to treat. Future therapies will be aimed at preventing or reversing remodelling, but in order to develop these therapies we need a greater knowledge of the remodelling process. Remodelling occurs in all three vascular layers and, in the past, most …