Journal article
Deep Brain Stimulation for Treatment-Resistant Depression
Abstract
Treatment-resistant depression is a severely disabling disorder with no proven treatment options once multiple medications, psychotherapy, and electroconvulsive therapy have failed. Based on our preliminary observation that the subgenual cingulate region (Brodmann area 25) is metabolically overactive in treatment-resistant depression, we studied whether the application of chronic deep brain stimulation to modulate BA25 could reduce this …
Authors
Mayberg HS; Lozano AM; Voon V; McNeely HE; Seminowicz D; Hamani C; Schwalb JM; Kennedy SH
Journal
Neuron, Vol. 45, No. 5, pp. 651–660
Publisher
Elsevier
Publication Date
March 2005
DOI
10.1016/j.neuron.2005.02.014
ISSN
0896-6273