Lipid rafts in binary lipid/cholesterol bilayers
Chapters
Overview
Additional Document Info
View All
Overview
abstract
The lipid membrane was once modelled as a homogeneous two-dimensional fluid,
however, it is in fact a patchy, inhomogeneous state of matter. Inhomogeneities in
membranes are now understood to be crucial to their function. These so-called lipid
rafts are described as lateral lipid assemblies enriched in cholesterol, which have a
greater degree of molecular order. They are believed to play a role in membrane bound
protein insertion, sorting, and function. However, size, lifetime, and even the existence
of rafts are still the subject of debate. This chapter discusses a role for lipid rafts in
membrane homeostasis, experimental techniques to detect rafts, and our current physical
models of how rafts may form. In particular, recent X-ray and neutron scattering
experiments will be highlighted, which have revealed the lateral molecular ordering
of cholesterol in lipid membranes, and have enhanced our understanding of lipid rafts.
Those experiments, in particular, demonstrated that a drug, such as aspirin, can interrupt
membrane homeostasis by influencing the formation of lipid rafts.
