Residual vein thrombosis for assessing duration of anticoagulation after unprovoked deep vein thrombosis of the lower limbs: The extended DACUS study Journal Articles uri icon

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  • AbstractThe safest duration of anticoagulation after idiopathic deep vein thrombosis (DVT) is unknown. We conducted a prospective study to assess the optimal duration of vitamin K antagonist (VKA) therapy considering the risk of recurrence of thrombosis according to residual vein thrombosis (RVT). Patients with a first unprovoked DVT were evaluated for the presence of RVT after 3 months of VKA administration; those without RVT suspended VKA, while those with RVT continued oral anticoagulation for up to 2 years. Recurrent thrombosis and/or bleeding events were recorded during treatment (RVT group) and 1 year after VKA withdrawal (both groups). Among 409 patients evaluated for unprovoked DVT, 33.2% (136 of 409 patients) did not have RVT and VKA was stopped. The remaining 273 (66.8%) patients with RVT received anticoagulants for an additional 21 months; during this period of treatment, recurrent venous thromboembolism and major bleeding occurred in 4.7% and 1.1% of patients, respectively. After VKA suspension, the rates of recurrent thrombotic events were 1.4% and 10.4% in the no‐RVT and RVT groups, respectively (relative risk = 7.4; 95% confidence interval = 4.9–9.9). These results indicate that in patients without RVT, a short period of treatment with a VKA is sufficient; in those with persistent RVT, treatment extended to 2 years substantially reduces, but does not eliminate, the risk of recurrent thrombosis. Am. J. Hematol. 2011. © 2011 Wiley‐Liss, Inc.


  • Siragusa, Sergio
  • Malato, Alessandra
  • Saccullo, Giorgia
  • Iorio, Alfonso
  • Di Ianni, Mauro
  • Caracciolo, Clementina
  • Coco, Lucio Lo
  • Raso, Simona
  • Santoro, Marco
  • Guarneri, Francesco Paolo
  • Tuttolomondo, Antonino
  • Pinto, Antonio
  • Pepe, Iliana
  • Casuccio, Alessandra
  • Abbadessa, Vincenzo
  • Licata, Giuseppe
  • Battista Rini, Giovan
  • Mariani, Guglielmo
  • Di Fede, Gaetana

publication date

  • November 2011