abstract
- Candesartan is an angiotensin receptor antagonist that is long acting, well absorbed from the gastrointestinal tract and demonstrates an insurmountable receptor antagonism. It is an effective once-daily antihypertensive therapy that maintains good control of blood pressure for over 24 h. More recently, candesartan was shown to be an effective therapy for heart failure patients, producing a significant reduction in mortality and morbidity. Importantly, the studies have demonstrated that candesartan is effective in heart failure patients intolerant to angiotensin-converting enzyme inhibitors (ACE-I), as well as in addition to ACE-I. This paper reviews the data supporting the use of candesartan to treat patients with clinical heart failure.