Journal article
The small ubiquitin-like modifier (SUMO) is required for gonadal and uterine-vulval morphogenesis in Caenorhabditis elegans
Abstract
The small ubiquitin-like modifier (SUMO) modification alters the subcellular distribution and function of its substrates. Here we show the major role of SUMO during the development of the Caenorhabditis elegans reproductive system. smo-1 deletion mutants develop into sterile adults with abnormal somatic gonad, germ line, and vulva. SMO-1::GFP reporter is highly expressed in the somatic reproductive system. smo-1 animals lack a vulval-uterine …
Authors
Broday L; Kolotuev I; Didier C; Bhoumik A; Gupta BP; Sternberg PW; Podbilewicz B; Ronai Z
Journal
Genes & Development, Vol. 18, No. 19, pp. 2380–2391
Publisher
Cold Spring Harbor Laboratory
Publication Date
October 1, 2004
DOI
10.1101/gad.1227104
ISSN
0890-9369