Brain-derived neurotrophic factor: the link between amyloid-β and memory loss Journal Articles

abstract

• Brain-derived neurotrophic factor (BDNF) is a critical molecule for learning and memory. Brain BDNF levels correlate with cognitive status. BDNF is downregulated in Alzheimer’s disease, in age-related cognitive impairment and in a variety of other neurodegenerative and psychiatric disorders exhibiting cognitive deficits. BDNF is downregulated in the Alzheimer’s disease brain by soluble, aggregated amyloid-β, acting via a pathway involving the transcription factor cAMP response element binding protein, which activates BDNF transcript IV. The complete pathway by which BDNF is downregulated is still unclear, and the diagnostic and therapeutic use of BDNF in neurodegenerative disease has not yet been exploited.

authors

• Fahnestock, Margaret

status

• published 

publication date

• September 2011

has subject area

• 1103 Clinical Sciences (FoR)
• 1109 Neurosciences (FoR)
• 1702 Cognitive Sciences (FoR)
• Neurology & Neurosurgery (Science Metrix)

published in

• Future Neurology  Journal

keywords

• 1 Underpinning research
• 1.1 Normal biological development and functioning
• 2 Aetiology
• 2.1 Biological and endogenous factors
• 32 Biomedical and Clinical Sciences
• 3202 Clinical Sciences
• 3209 Neurosciences
• Acquired Cognitive Impairment
• Aging
• Alzheimer's Disease
• Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD)
• Brain Disorders
• Dementia
• Genetics
• Mental health
• Neurodegenerative
• Neurological
• Neurosciences

Digital Object Identifier (DOI)

• 10.2217/fnl.11.44

start page

• 627

end page

• 639

volume

• 6

issue

• 5