Generation of Precursors and Primitive Human Hematopoietic Cells from Human ESC Lines

Establishment of pluripotent human embryonic stem cell (hESC) lines has given rise to new opportunities for regenerative-based medicine. The use of hESC lines is further complicated by the now recognized differences in murine embryonic stem cells (mESCs) versus hESCs. Although it is difficult to accept, based on the developmental similarities between the species, hESCs, unlike mESCs, possess distinct growth and differentiation requirements. …