Journal article
Clonal interrogation of stem cells
Abstract
Individual stem cells are functionally defined by their self-renewal and differentiation potential. Methods for clonal analysis are essential for understanding stem cells, particularly given the increasing evidence for stem-cell heterogeneity. Stem cells reside within complex microenvironments, making single-cell analysis particularly challenging. Furthermore, simultaneous molecular and functional characterization of single stem cells is not …
Authors
Hope K; Bhatia M
Journal
Nature Methods, Vol. 8, No. Suppl 4, pp. s36–s40
Publisher
Springer Nature
Publication Date
April 2011
DOI
10.1038/nmeth.1590
ISSN
1548-7091