Two-dimensional image sensor arrays incorporating an organic light sensor are reported, with potential application to digital cameras and x-ray imaging. The 512×512 element array has pixel size of 100 micron, and operates with active matrix addressing using amorphous silicon thin film transistors. The array design allows the use of a continuous layer of the organic sensor material without the need for pixel-level patterning. The sensor is a bilayer comprising a thin generator layer and a thicker hole transport layer. Generator materials benzimidazole perylene (BZP) and hydroxy gallium phthalocyanine (HOGaPc) have been studied, with a tetraphenyldiamine (TPD) transport layer. Both sensors give excellent imaging properties with low leakage current, good charge collection and high spatial resolution.