Osaic hydrogels: One-step formation of multiscale soft materials

We introduce the one-step, continuous formation of mosaic hydrogel sheets. A microfluidic device allows controllable incorporation of secondary biopolymers within a flowing biopolymer sheet followed by a cross-linking step that retains the microscale composition. Information is encoded, mosaic stiffness and diffusivity patterns are created, and tessellations are populated with biomolecules, microparticles and viable primary cells. The extension …