Platelet adhesion to a plasminogen-specific surface (lysine-derivatized polyethylene) from whole blood

The interactions of analogous lysine-polyethylene surfaces with fibronogen and platelets in plasma and whole blood contact were discussed. It was found that the unmodified low density polyethylene (LDPE) adsorbed the most fibrinogen and the polyvinyl pyrrolidone (PVP) the least, with the lysien surfaces intermediate. It was also found that the adsorption of plasminogen in large quantity to the ε-lysine surface appears to have neither inhibitory nor a stimulatory effect of platelet surface-interactions. The results show that the ε-lysine material has strong antithrombogenic potential due to its low platelet adhesion as well as its fibrinolytic activity.