Neurogenic and myogenic motor patterns of distal colon in rats in vitro

To explore the motor patterns of distal colon and their features in rats in vitro. Spatiotemporal mapping and pharmaceutical intervention were used to investigate the motor activities of the distal colon and their neurogenic and myogenic features in 35 healthy Sprague Dawley rats. Motor patterns like rhythmic propulsive motor complexes, ripples, segmentation, and long distance contraction (LDC) were observed in healthy rats. LDC reached the distal colon and formed various combinations with other patterns. Tetrodotoxin and lidocaine inhibited LDC, and changed motor complexes, promoted ripples and induced segmentation in distal colon. L-NNA inhibited LDC and changed motor complexes. Distal colon has various motor patterns like LDC, rhythmic motor complexes, ripples, segmentation, and retrograde contractions in rats in vitro.