Soft X-ray spectromicroscopy of fibrinogen on polystyrene: Poly(methyl methacrylate) polymer blend surface

The surface structure of a copolymer blend of polystyrene (PS) and polymethylmethacrylate (PMMA) and the adsorption of human fibrinogen (Fg) on this surface was investigated. It was observed that the saturation adsorption at higher concentrations was in the range of close-packed monolayers for the three polymer blend surfaces which were PS, PMMA and the PS:PMMA blend surfaces. Over a similar concentration range in buffer, adsorption was greater on PS than PMMA, with the blend intermediate. Similar measurements in deionized (DI) water showed that the PS:PMMA interface was the preferred site of Fg attachment.