Tetrameric Ctp1 coordinates DNA binding and DNA...

Tetrameric Ctp1 coordinates DNA binding and DNA bridging in DNA double-strand-break repair

Abstract

Structural, biophysical and genetic analyses reveal that Schizosaccharomyces pombe Ctp1 forms a flexible tetramer with multivalent DNA-binding and bridging activities that contribute to Ctp1's role in repair of DNA double-strand breaks.

Authors

Andres SN; Appel CD; Westmoreland JW; Williams JS; Nguyen Y; Robertson PD; Resnick MA; Williams RS

Journal

Nature Structural & Molecular Biology, Vol. 22, No. 2, pp. 158–166

Publisher

Springer Nature

Publication Date

January 1, 2015

DOI

10.1038/nsmb.2945

ISSN

1545-9993

Associated Experts

Sara Andres

Associate Professor, Faculty of Health Sciences

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