Journal article
Evaluation of a 68Ga-Labeled DOTA-Tetrazine as a PET Alternative to 111In-SPECT Pretargeted Imaging
Abstract
The bioorthogonal reaction between a tetrazine and strained transcyclooctene (TCO) has garnered success in pretargeted imaging. This reaction was first validated in nuclear imaging using an 111In-labeled 1,4,7,10tetraazacyclododecane1,4,7,10tetraacetic acid (DOTA)-linked bispyridyl tetrazine (Tz) ([111In]In-DOTA-PEG11-Tz) and a TCO functionalized CC49 antibody. Given the initial success of this Tz, it has been paired with TCO functionalized …
Authors
Edem PE; Jørgensen JT; Nørregaard K; Rossin R; Yazdani A; Valliant JF; Robillard M; Herth MM; Kjaer A
Journal
Molecules, Vol. 25, No. 3,
Publisher
MDPI
DOI
10.3390/molecules25030463
ISSN
1431-5157