Highly Efficient Multigram Synthesis of Dibenzoazacyclooctyne (DBCO) without Chromatography

The synthesis of 4-[11,12-didehydrodibenzo­[b,f]­azocin-5­(6H)-yl]-4-oxobutanoic acid, also known as dibenzoazacyclooctyne (DBCO) or aza-dibenzocyclooctyne (ADIBO), was optimized for large-scale preparations of at least 10 g with an overall yield of 42%.