Journal article
Highly Efficient Multigram Synthesis of Dibenzoazacyclooctyne (DBCO) without Chromatography
Abstract
The synthesis of 4-[11,12-didehydrodibenzo[b,f]azocin-5(6H)-yl]-4-oxobutanoic acid, also known as dibenzoazacyclooctyne (DBCO) or aza-dibenzocyclooctyne (ADIBO), was optimized for large-scale preparations of at least 10 g with an overall yield of 42%.
Authors
McNelles SA; Pantaleo JL; Adronov A
Journal
Organic Process Research & Development, Vol. 23, No. 12, pp. 2740–2745
Publisher
American Chemical Society (ACS)
Publication Date
December 20, 2019
DOI
10.1021/acs.oprd.9b00406
ISSN
1083-6160